Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium.
نویسندگان
چکیده
Forward mutation to 8-azaguanine resistance and reverse mutation to histidine prototrophy were measured in Salmonella typhimurium after treatment with 16 mutagens of both base-substitution and frameshift classes. The two approaches were found to be equisensitive for all 16 mutagens--i.e., induction of significant mutation occurred at similar concentrations in the forward mutation assay and in the most sensitive of the five Ames tester strains.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 75 9 شماره
صفحات -
تاریخ انتشار 1978